Scientific and Innovation Activities
Mission of Scientific and Innovation Activities
Conducting fundamental and applied research in the fields of biology, medicine and pharmacy; training of highly qualified scientific and pedagogical personnel.
Infrastructure
Promising Areas of Scientific and Innovation Activities:
- development of pharmacological compounds of synthetic, natural and biotechnological origin;
- preclinical studies of efficacy and safety (assessment of neurotropic, psychotropic, immunotropic, antimicrobial, anti-inflammatory and regenerative activity; assessment of acute and chronic drug toxicity of general and organotropic effects, etc.), full cycle “in vitro → in vivo”;
- isolation and study of the efficacy and safety of bacteriophages;
- microbiological, molecular genetic and immunobiological research;
- development of diagnostic test systems based on ELISA, PCR, biochemical and molecular genetic principles;
- clinical research aimed at solving practical healthcare challenges within the framework of preventive and personalized medicine.
Scientific Supervisor: Sergey Petrovich Sinchikhin, Doctor of Medical Sciences, Professor, Head of the Department of Obstetrics and Gynecology of the Faculty of General Medicine, doc_sinchihin@mail.ru
Personalized Strategies for Preconception Correction
Development of a systemic algorithm for personalized preconception correction based on multilevel phenotyping of patients.
Key Scientific Idea
Multilevel phenotyping of a patient (genetic, metabolic, hormonal, immune, microbiome and structural-anatomical) will make it possible to develop an individual strategy for the correction of reproductive disorders, increasing the chances of achieving reproductive function and the overall effectiveness of ART (assisted reproductive technologies). Development of a clinical algorithm for personalized preparation will reduce the number of diagnostic and therapeutic procedures and increase the overall effectiveness of ART. The establishment of a new scientific field at the intersection of reproductive medicine, bioinformatics and nutrigenomics, as well as the development of a classification of phenotypes of preconception disorders, may serve as a basis for further research.
Resources of Astrakhan State Medical University
Scientific Supervisor: Anna Leonidovna Yasenyavskaya, Doctor of Medical Sciences, Associate Professor, Head of the Department of Pharmacognosy, Pharmaceutical Technology and Biotechnology, kaf_fftb@astgmu.ru
Biological Resources and Pharmacological Potential of the Flora of Arid Territories
Key Scientific Idea
The project is aimed at determining the pharmacological potential of plants of the flora of arid territories with unique climatic characteristics that shape specific adaptive properties in plants, making them a promising object for the search for new sources of biologically active substances. The concept is based on comprehensive screening of the biological effects of plant samples in whole organisms using behavioral tests, assessment of biochemical markers of inflammation and stress, and molecular verification, which makes it possible to evaluate their pharmacological properties - anti-inflammatory, anxiolytic, antidepressant, adaptogenic, immunotropic, etc.
The Astrakhan Region, as a territory of the Caspian macroregion, is of interest as a promising site for the cultivation of plant species with the aim of establishing clusters for the development of phytopharmaceuticals. Currently, the Chinese side is already implementing similar projects to establish plantations and medicinal plant clusters in other Russian territories (Altai, Smolensk Region) and is interested in scaling this experience to regions with similar agro-climatic conditions. The scientific significance lies in the creation of the first experimental database on the biological activity of the Astrakhan flora; the practical significance lies in the development of a scientifically grounded list of promising plant species for joint projects with the PRC on the cultivation of raw materials and the preclinical development of phytopharmaceuticals.
Resources of Astrakhan State Medical University
Scientific Supervisor: Lyudmila Petrovna Voronina, Doctor of Medical Sciences, Professor, Head of the Department of Clinical Immunology with a Postgraduate Education Course, kaf_klinim@astgmu.ru
Integrative Biomarker Cardiology: Proteomic and Sonographic Determinants of Chronic Heart Failure for Precision Prognosis and Rehabilitation
Key Scientific Idea
The use of combinations of proteomic markers (H-FABP, cardiotrophin-1, galectin-3, surfactant protein-D) in the assessment of cardiorespiratory interaction in chronic heart failure (CHF) with the aim of developing precision prognostic models and personalized cardiac rehabilitation programs.
Resources of Astrakhan State Medical University
Scientific Supervisor: Elena Igorevna Kashirskaya, Doctor of Medical Sciences, Associate Professor, Head of the Department of Hospital Pediatrics and Neonatology, kaf_pedneo@astgmu.ru
Comparative Study of Population-Specific Characteristics of Congenital Heart Defects
The study proposes a direct comparative analysis of the genetic and clinical characteristics of congenital heart defects (CHDs) in Russian and Chinese children - for the first time in the format of a systematic cross-cultural comparison using independent cohorts.
Key Scientific Idea
Conducting a comparative analysis of specific characteristics of congenital heart defects in Russian and Chinese pediatric populations, including the use of a genomic approach and the search for specific mutations.
Resources of Astrakhan State Medical University
Scientific Supervisor: Bela Ismailovna Kantemirova, Doctor of Medical Sciences, Professor, Head of the Department of Pharmacology, kaf_farm@astgmu.ru
Algorithms for the Personalized Prescription of Essential Medicines Taking into Account Genetic and Modifiable Factors
The study proposes practice-oriented algorithms for the personalized prescription of medicines, taking into account genetic, ethnic and clinical factors.
Key Scientific Idea
Development of algorithms for the personalized prescription of essential medicines, taking into account the genetic/ethnic characteristics of patients with various pathologies, risk factors for the development of complications, comorbid conditions and phenotypic characteristics.
Resources of Astrakhan State Medical University
Scientific Supervisor: Zhuzhuna Murmanovna Tsotsonava, Candidate of Medical Sciences, Associate Professor, Head of the Department of Neurology and Neurosurgery with a Postgraduate Education Course, tsotsonava02@yandex.ru
Neuroplasticity and Cognitive Reserve: Integrative Technologies for Early Intervention in Age-Related and Vascular Brain Disorders
Key Scientific Idea
Development of a multilevel system for predicting and correcting cognitive decline based on the synergy of three components: neuroimaging (structural and functional magnetic resonance imaging) and biochemical (apolipoprotein E, neuroinflammatory cytokines, BDNF) biomarkers, as well as digital cognitive trackers (computerized batteries with machine-based data processing).
